Annual Review of Genetics
The molecular mechanisms for the transduction of light and chemical
signals in animals are fairly well understood. In contrast, the processes by which the
senses of touch, balance, hearing, and proprioception are transduced are still largely
unknown. Biochemical approaches to identify transduction components are difficult to
use with mechanosensory systems, but genetic approaches are proving more successful.
Genetic research in several organisms has demonstrated the importance of cytoskeletal,
extracellular, and membrane components for sensory mechanotransduction. In particular,
researchers have identified channel proteins in the DEG/ENaC and TRP families
that are necessary for signaling in a variety of mechanosensory cells. Proof that these
proteins are components of the transduction channel, however, is incomplete.
Created by eritakami
3 years 21 weeks ago – Made popular 3 years 21 weeks ago
Category: Cytoskeletal Dynamics