Year of publication:
2009
Journal name:
PubMed
Upstream mechanotaxis behavior of endothelial cells
http://www.ncbi.nlm.nih.gov –
Vascular endothelial cell migration, which plays an important role in vascular remodeling, is known to be regulated by hemodynamic forces in the blood vessels. When shear stress is applied on mouse microvessel endothelial cells (bEnd.3) in vitro, cells exhibit upstream migration behavior with respect to the direction of the flow. To determine how shear stress magnitude influences mechanotaxis of the cells, endothelial cells were exposed to different magnitudes of unidirectional shear stress. Read more »
Category: Endothelial and Smooth Muscle Tags:
Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature
http://www.springerlink.com –
Transient receptor potential (TRP) ion channel superfamily is involved in sensing and transmission of a broad variety of external or internal stimuli, including but not limited to mechanical stress. Based on homology analysis, genetic and molecular studies have recently identified TRP channels in different tissues, comprising blood vessels. In invertebrates, many TRP channels including five TRPV channels identified in Caenorhabditis elegans and two in Drosophila have been implicated in mechanosensory behaviors as molecular basis of volume regulation, hearing and touch sensitivity. Read more »
Year of publication:
2009
Journal name:
Cell Biochemistry and Biophysics