Year of publication:
2005
Journal name:
The Journal of Neuroscience
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing
http://www.jneurosci.org –
Mechanosensory channels of sensory cells mediate the sensations of hearing, touch, and some forms of pain. The TRPA1 (a member of the TRP family of ion channel proteins) channel is activated by pain-producing chemicals, and its inhibition impairs hair cell mechanotransduction. As shown here and previously, TRPA1 is expressed by hair cells as well as by most nociceptors (small neurons of dorsal root, trigeminal, and nodose ganglia) and localizes to their sensory terminals (mechanosensory stereocilia and peripheral free nerves, respectively). Read more »
Mechanotransduction in vertebrate hair cells: structure and function of the stereociliary bundle
http://ajpcell.physiology.org –
The mechanosensitive hair cells of the vertebrate acousticolateralis system have an apical bundle of stereocilia, deflections of which control the opening of mechano-electrical transduction channels and thus generate receptor potentials in the cell below. This review describes current theories of hair cell function in the light of recent immunocytochemical and ultrastructural findings; in particular, the location and operation of the transduction channels are considered. Read more »
Year of publication:
1995
Journal name:
American Journal of Physiology - Cell Physiology