Year of publication:
2005
Journal name:
Annual Review of Biomedical Engineering Volume 7
BIOCHEMISTRY AND BIOMECHANICS OF CELL MOTILITY
http://arjournals.annualreviews.org –
Cell motility is an essential cellular process for a variety of biological events. The process of cell migration requires the integration and coordination of complex biochemical and biomechanical signals. The protrusion force at the leading edge of a cell is generated by the cytoskeleton, and this force generation is controlled by multiple signaling cascades. The formation of new adhesions at the front and the release of adhesions at the rear involve the outside-in and inside-out signaling mediated by integrins and other adhesion receptors. Read more »
Microfabricated Post-Array-Detectors (mPADs): an Approach to Isolate Mechanical Forces
http://www.ncbi.nlm.nih.gov –
In a variety of situations in living organisms, cells interact with their environment by generating traction forces. For example, muscle contractility (cardiac, skeletal and smooth muscles), ECs and permeability, stem cell differentiation might correlate with contractility (maybe…Engler). There are currently few methods by which one can measure the traction forces in a quantitative way, especially on the single-cell level; the most common method by which to study cells in vitro has been to use a polystyrene dish. Read more »
Year of publication:
2007
Journal name:
Journal of Visualized Experiments