Year of publication:
2009
Journal name:
Biology of the Cell
Focal adhesion kinase-dependent regulation of adhesive force involves vinculin recruitment to focal adhesions.
http://www.ncbi.nlm.nih.gov –
Background information. Focal adhesion kinase (FAK), an essential non-receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signaling, and mechanotransduction. FAK-dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion. Whereas roles for FAK in migratory and mechanosensing responses have been established, the contributions of FAK to the generation of adhesive forces are not well understood. Results. Read more »
Minireview: A Tiny Touch: Activation of Cell Signaling Pathways with Magnetic Nanoparticles.
http://www.ncbi.nlm.nih.gov –
Magnetic nanoparticles can be coated with specific ligands that enable them to bind to receptors on a cell's surface. When a magnetic field is applied, it pulls on the particles so that they deliver nanoscale forces at the ligand-receptor bond. It has been observed that mechanical stimulation in this manner can activate cellular signaling pathways that are known as mechanotransduction pathways. Read more »
Year of publication:
2009
Journal name:
Endocrinology