Year of publication:
2001
Journal name:
The American Physiological Society
Mechanotransduction in the Lung; Ventilation-induced lung injury and mechanotransduction: stretching it too far?
http://ajplung.physiology.org –
The Acute Respiratory Distress Syndrome Network clinical trial on ventilation of critically ill patients has drawn attention to the potential side effects of mechanical ventilation. Both clinical and basic research have demonstrated that injurious ventilation strategies can initiate or perpetuate local and systemic inflammatory responses. There are four principal mechanisms that can produce such a response. Read more »
Cellular mechanics and gene expression in blood vessels
http://www.sciencedirect.com –
Blood vessels are permanently subjected to mechanical forces in the form of stretch, encompassing cyclic mechanical strain due to the pulsatile nature of blood flow, and shear stress. Alterations in stretch or shear stress invariably produce transformations in the vessel wall that will aim to accommodate the new conditions and to ultimately restore basal levels of tensile stress and shear stress. Vascular cells are equipped with numerous receptors that allow them to detect and respond to the mechanical forces generated by pressure and shear stress. Read more »
Year of publication:
2003
Journal name:
Cardiovascular Biomechanics