http://linkinghub.elsevier.com – Several in vivo and in vitro studies with different loading regimens showed that mechanical stimuli have an influence on proliferation and differentiation of bone cells. Prerequisite for this influence is the transduction of mechanical signals into the cell, a phenomenon that is termed mechanotransduction, which is essential for the maintenance of skeletal homeostasis in adults. Read more »

http://www.sciencedirect.com – This bone mechanosensory hypothesis is partially sustained by experi- mental evidence and model calculations that will be described. The ques- tions addressed by these studies include the following: (a) Which cells (osteoblasts, osteocytes, bone-lining cells) are the bone mechanosensors? (b) What mechanical stimulus activates the mechanosensor? And (c) How is a local mechanical signal translated into an anabolic or catabolic event? Over the last decade, important progress has been made related to these questions, that will be reviewed here. Read more »