Year of publication:
2007
Journal name:
Philosophical Transaction of Royal Society B
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering
http://www.childrenshospital.org –
The spatial and temporal scales of cardiac organogenesis and pathogenesis make engineering of
artificial heart tissue a daunting challenge. The temporal scales range from nanosecond conformational changes responsible for ion channel opening to fibrillation which occurs over Read more »
Microfabricated Post-Array-Detectors (mPADs): an Approach to Isolate Mechanical Forces
http://www.ncbi.nlm.nih.gov –
In a variety of situations in living organisms, cells interact with their environment by generating traction forces. For example, muscle contractility (cardiac, skeletal and smooth muscles), ECs and permeability, stem cell differentiation might correlate with contractility (maybe…Engler). There are currently few methods by which one can measure the traction forces in a quantitative way, especially on the single-cell level; the most common method by which to study cells in vitro has been to use a polystyrene dish. Read more »
Year of publication:
2007
Journal name:
Journal of Visualized Experiments