Mechanosensitivity

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Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.

http://www.ncbi.nlm.nih.gov Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease, requiring cardiac myocytes to be mechanically durable and capable of fusing a variety of environmental signals on different time scales. During physiological growth, myocytes adaptively remodel to mechanical loads. Pathological stimuli can induce maladaptive remodeling. Read more »
hamedsheik's picture
Created by hamedsheik 46 weeks 5 days ago – Made popular 46 weeks 5 days ago
Category: Cardiovascular   Tags:
15

Environmental sensing through focal adhesions.

http://www.ncbi.nlm.nih.gov Recent progress in the design and application of artificial cellular microenvironments and nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal organization, and hence their shape and motility, to minute changes in their immediate surroundings. Read more »
2

Mechanisms of Mechanotransduction

http://www.sciencedirect.com
Year of publication: 
2006
Journal name: 
Developmental Cell
The conversion of physical force into biochemical information is fundamental to development and physiology. It provides a simple means by which cells and organisms can ensure structural stability, as well as a way to regulate morphogenetic movements to generate precise three-dimensional structures. In the vascular system, pressure and shear stress from pumping blood influence the morphology and pathology of the heart and vasculature. Bone is shaped by forces from gravity and muscle contraction. Hearing and touch are based on neural responses to pressure. Read more »
rjr's picture
Created by rjr 3 years 23 weeks ago – Made popular 3 years 22 weeks ago
Category: Cell Mechanotransduction   Tags:
4

Mechanosensitive ion channels: molecules of mechanotransduction

http://jcs.biologists.org
Year of publication: 
2004
Journal name: 
Journal of Cell Science
Cells respond to a wide variety of mechanical stimuli, ranging from thermal molecular agitation to potentially destructive cell swelling caused by osmotic pressure gradients. The cell membrane presents a major target of the external mechanical forces that act upon a cell, and mechanosensitive (MS) ion channels play a crucial role in the physiology of mechanotransduction. These detect and transduce external mechanical forces into electrical and/or chemical intracellular signals. Read more »
nguyen.olivia's picture
Created by nguyen.olivia 3 years 32 weeks ago – Made popular 3 years 21 weeks ago
Category: Other   Tags:

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