Year of publication:
2010
Journal name:
The Annals of Thoracic Surgery
Effect of Adjustable Passive Constraint on the Failing Left Ventricle: A Finite-Element Model Study
http://www.sciencedirect.com –
Background
Passive constraint is used to prevent left ventricular dilation and subsequent remodeling. However, there has been concern about the effect of passive constraint on diastolic left ventricular chamber stiffness and pump function. This study determined the relationship between constraint, diastolic wall stress, chamber stiffness, and pump function. We tested the hypothesis that passive constraint at 3 mm Hg reduces wall stress with minimal change in pump function.
Methods Read more »
Category: Cardiovascular Tags:
Cardiac mechanotransduction: from sensing to disease and treatment
http://www.sciencedirect.com –
In heart muscle a mechanical stimulus is sensed and transformed into adaptive changes in cardiac function by a process called mechanotransduction. Adaptation of heart muscle to mechanical load consists of neurohumoral activation and growth, both of which decrease the initial load. Under prolonged overload this process becomes maladaptive, leading to the development of left ventricular hypertrophy and ultimately to heart failure. Read more »
Year of publication:
2001
Journal name:
Trends in Pharmacological Sciences