Year of publication:
1999
Journal name:
The Journal of Biological Chemistry
Mechanotransduction in Response to Shear Stress: Roles of Receptor Tyrosine Kinases, Integrins, and Shc
http://www.jbc.org –
Shear stress, the tangential component of hemodynamic forces, activates many signal transduction pathways in vascular endothelial cells. The conversion of mechanical stimulation into chemical signals is still unclear. We report here that shear stress (12 dynes/cm2) induced a rapid and transient tyrosine phosphorylation of Flk-1 and its concomitant association with the adaptor protein Shc; these are accompanied by a concurrent clustering of Flk-1, as demonstrated by confocal microscopy. Read more »
Upstream mechanotaxis behavior of endothelial cells
http://www.ncbi.nlm.nih.gov –
Vascular endothelial cell migration, which plays an important role in vascular remodeling, is known to be regulated by hemodynamic forces in the blood vessels. When shear stress is applied on mouse microvessel endothelial cells (bEnd.3) in vitro, cells exhibit upstream migration behavior with respect to the direction of the flow. To determine how shear stress magnitude influences mechanotaxis of the cells, endothelial cells were exposed to different magnitudes of unidirectional shear stress. Read more »
Year of publication:
2009
Journal name:
PubMed
Category: Endothelial and Smooth Muscle Tags: