Year of publication:
2007
Journal name:
Annual Reviews Biochemistry
Structural biology of nucleocytoplasmic transport.
http://www.ncbi.nlm.nih.gov –
In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and protein synthesis in the cytoplasm poses the requirement of transporting thousands of macromolecules between the two cellular compartments. Transport between nucleus and cytoplasm is mediated by soluble receptors that recognize specific cargoes and carry them through the nuclear pore complex (NPC), the sole gateway between the two compartments at interphase. Read more »
Category: Nuclear Pore Complex Tags:
Nuclear Pore Complex: Biochemistry and Biophysics of Nucleocytoplasmic Transport in Health and Disease
http://biomechanics.berkeley.edu –
Nuclear pore complexes (NPCs) are the gateways connecting the nucleoplasm and cytoplasm. This structures are composed of over 30 different proteins and 60–125 MDa of mass depending on type of species. NPCs are bilateral pathways that selectively control the passage of macromolecules into and out of the nucleus. Molecules smaller than 40 kDa diffuse through the NPC passively while larger molecules require facilitated transport provided by their attach- ment to karyopherins. Kinetic studies have shown that approximately 1000 translocations occur per second per NPC. Read more »
Category: Nuclear Pore Complex Tags: