Year of publication:
1999
Journal name:
The Journal of Biological Chemistry
Endostatin Induces Endothelial Cell Apoptosis
http://www.jbc.org –
Endostatin, a carboxyl-terminal fragment of collagen XVIII, has been shown to regress tumors in mice. In this study, we have analyzed the mechanism of endostatin action on endothelial cells and nonendothelial cells. Endostatin treatment of cow pulmonary artery endothelial cells caused apoptosis, as demonstrated by three methods, annexin V-fluorescein isothiocyanate staining, caspase 3, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling assay. Read more »
Category: Endothelial and Smooth Muscle Tags:
Mechanotransduction in endothelial cell migration
http://www3.interscience.wiley.com –
The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration and mechanotransduction can be modulated by cytoskeleton, cell surface receptors such as integrins and proteoglycans, the chemical and physical properties of extracellular matrix (ECM) and cell-cell adhesions. Read more »
Year of publication:
2005
Journal name:
Mechanotransduction in endothelial cell migration
Category: Cell Mechanotransduction Tags:
Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology
http://circres.ahajournals.org –
Great advances have been made in the identification of the soluble angiogenic factors, insoluble extracellular matrix (ECM) molecules, and receptor signaling pathways that mediate control of angiogenesis—the growth of blood capillaries. This review focuses on work that explores how endothelial cells integrate these chemical signals with mechanical cues from their local tissue microenvironment so as to produce functional capillary networks that exhibit specialized form as well as function. Read more »
Year of publication:
2002
Journal name:
Circulation Research
Shear Stress Inhibits Smooth Muscle Cell
http://journal.shouxi.net –
Vascular endothelial cells (ECs) are influenced by shear stress and neighboring smooth muscle cells (SMCs). We investigated the inflammation-relevant gene expression in EC/SMC cocultures under static condition and in response to shear stress. Our findings suggest that shear stress plays an inhibitory role in the proinflammatory gene expression in ECs located in close proximity to SMCs. ECs are influenced by shear stress and SMCs. DNA microarrays showed increased proinflammatory gene expressions in ECs by static SMC coculture. Shear stress inhibits these coculture-induced expressions. Read more »
Year of publication:
2006
Journal name:
National Health Research Institutes, Miaoli, Taiwan
Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets
http://www.sciencedirect.com –
Background: Sheets of cells move together as a unit during wound healing and embryonic tissue movements, such as those occurring during gastrulation and neurulation. We have used epithelial wound closure as a model system for such movements and examined the mechanisms of closure and the importance of the Rho family of Ras-related small GTPases in this process. Read more »
Year of publication:
2000
Journal name:
Current Biology