Year of publication:
2002
Journal name:
Journal of Orthopaedic Research
Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain
http://www.flexcellint.com –
Cyclic strain has been shown to benefit tendon health. However, repetitive loading has also been implicated in the etiology of
tendon overuse injuries. Recent studies demonstrated that in several cell lines cyclic strain was associated with an activation of
stress-activated protein kinases (SAPKs). These SAPKs, in turn, were shown to be important upstream regulators of a variety of cell
processes including apoptosis. To examine the effect of repetitive loading on SAPK activation in tendon cells in vitro, canine patellar Read more »
Category: Tissue Mechanotransduction Tags:
Effect of Focal Adhesion Proteins on Endothelial Cell Adhesion, Motility and Orientation Response to Cyclic Strain.
http://www.ncbi.nlm.nih.gov –
Focal adhesion proteins link cell surface integrins and intracellular actin stress fibers and therefore play an important role in mechanotransduction and cell motility. When endothelial cells are subjected to cyclic mechanical strain, time-lapse imaging revealed that cells underwent significant morphological changes with their resultant long axes aligned away from the strain direction. To explore how this response is regulated by focal adhesion-associated proteins the expression levels of paxillin, focal adhesion kinase (FAK), and zyxin were knocked down using gene silencing techniques. Read more »
Year of publication:
2009
Journal name:
Annals of Biomedical Engineering