Year of publication:
2002
Journal name:
Circulation Research
Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology
http://circres.ahajournals.org –
Great advances have been made in the identification of the soluble angiogenic factors, insoluble extracellular matrix (ECM) molecules, and receptor signaling pathways that mediate control of angiogenesis—the growth of blood capillaries. This review focuses on work that explores how endothelial cells integrate these chemical signals with mechanical cues from their local tissue microenvironment so as to produce functional capillary networks that exhibit specialized form as well as function. Read more »
Interstitial Fluid Flow Intensity Modulates Endothelial Sprouting in Restricted Src-Activated Cell Clusters During Capillary Morphogenesis
http://web.mit.edu –
Development of tissues in vitro with dimensions larger than 150 to 200 mm requires the presence of a functional
vascular network. Therefore, we have studied capillary morphogenesis under controlled biological and biophysical
conditions with the aim of promoting vascular structures in tissue constructs. We and others have
previously demonstrated that physiological values of interstitial fluid flow normal to an endothelial monolayer
in combination with vascular endothelial growth factor play a critical role during capillary morphogenesis by Read more »
Year of publication:
2008
Journal name:
Tissue Engineering
Category: Tissue Mechanotransduction Tags: