Year of publication:
2009
Journal name:
Mechanics Research Communications
A model for mechanical adaptation of trabecular bone incorporating cellular accommodation and effects of microdamage and disuse
http://www.sciencedirect.com –
The purpose of this research is to improve a semi-mechanistic bone remodeling theory. In addition to entering the cellular accommodation effect into the model, a novel unifying formulation to include the effects of both microdamage and disuse on activation of resorption as the first phase of remodeling was introduced. Using the modified model, trabecular-like structures for different loading conditions and directionalities similar to actual human trabecular bone have been resulted. Read more »
Mechanotransduction in osteoblast regulation and bone disease.
http://www.ncbi.nlm.nih.gov –
Osteoblasts are key components of the bone multicellular unit and have a seminal role in bone remodeling, which is an essential function for the maintenance of the structural integrity and metabolic capacity of the skeleton. The coordinated function of skeletal cells is regulated by several hormones, growth factors and mechanical cues that act via interconnected signaling networks, resulting in the activation of specific transcription factors and, in turn, their target genes. Read more »
Year of publication:
2009
Journal name:
Trends in Molecular Medicine
Category: Developmental Cells Tags: