Year of publication:
1995
Journal name:
Calcified Tissue International
Mechanotransduction and the functional response of bone to mechanical strain
http://www.springerlink.com –
Mechanotransduction plays a crucial role in the physiology of many tissues including bone. Mechanical loading can inhibit bone resorption and increase bone formation in vivo. In bone, the process of mechanotransduction can be divided into four distinct steps: (1) mechanocoupling, (2) biochemical coupling, (3) transmission of signal, and (4) effector cell response. In mechanocoupling, mechanical loads in vivo cause deformations in bone that stretch bone cells within and lining the bone matrix and create fluid movement within the canaliculae of bone. Read more »
Mechanotransduction in Bone
http://www.sciencedirect.com –
This bone mechanosensory hypothesis is partially sustained by experi- mental evidence and model calculations that will be described. The ques- tions addressed by these studies include the following: (a) Which cells (osteoblasts, osteocytes, bone-lining cells) are the bone mechanosensors? (b) What mechanical stimulus activates the mechanosensor? And (c) How is a local mechanical signal translated into an anabolic or catabolic event? Over the last decade, important progress has been made related to these questions, that will be reviewed here. Read more »
Year of publication:
1998
Journal name:
Advances in Organ Biology