Year of publication:
2006
Journal name:
Georgia Tech Theses and Dissertations
Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading
http://smartech.gatech.edu –
Disease and degeneration of articular cartilage and fibrocartilage tissues severely compromise the quality of life for millions of people. Although current surgical repair techniques can address symptoms in the short term, they do not adequately treat degenerative joint diseases such as osteoarthritis. Thus, novel tissue engineering strategies may be necessary to combat disease progression and repair or replace damaged tissue. Read more »
Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues
http://www.pnas.org –
Physical forces generated by cells drive morphologic changes
during development and can feedback to regulate cellular phenotypes.
Because these phenomena typically occur within a 3-dimensional
(3D) matrix in vivo, we used microelectromechanical systems
(MEMS) technology to generate arrays of microtissues consisting
of cells encapsulated within 3D micropatterned matrices. Microcantilevers
were used to simultaneously constrain the remodeling
of a collagen gel and to report forces generated during this process.
By concurrently measuring forces and observing matrix remodeling Read more »
Year of publication:
2009
Journal name:
PNAS
The Finite Element Method: a Tool to Study Orthodontic Tooth Movement
http://jdr.sagepub.com –
Orthodontic tooth movement is achieved by (re)modeling processes of the alveolar bone, which are triggered by changes in the stress/strain distribution in the periodontium. In the past, the finite element (FE) method has been used to describe the stressed situation within the periodontal ligament (PDL) and surrounding alveolar bone. The present study sought to determine the impact of the modeling process on the outcome from FE analyses and to relate these findings to the current theories on orthodontic tooth movement. Read more »
Year of publication:
2005
Journal name:
Journal of Dental Research
Category: Tissue Mechanotransduction Tags:
Molecular mechanics of the alpha-actinin rod domain: bending, torsional, and extensional behavior.
http://www.ncbi.nlm.nih.gov –
alpha-Actinin is an actin crosslinking molecule that can serve as a scaffold and maintain dynamic actin filament networks. As a crosslinker in the stressed cytoskeleton, alpha-actinin can retain conformation, function, and strength. alpha-Actinin has an actin binding domain and a calmodulin homology domain separated by a long rod domain. Read more »
Year of publication:
2009
Journal name:
PLoS Computational Biology
Category: Cytoskeletal Dynamics Tags: