Year of publication:
2009
Journal name:
Nat Rev Mol Cell Bio
Mechanotransduction in vascular physiology and atherogenesis
http://www.ncbi.nlm.nih.gov:80 –
Forces associated with blood flow are major determinants of vascular morphogenesis and physiology. Blood flow is crucial for blood vessel development during embryogenesis and for regulation of vessel diameter in adult life. It is also a key factor in atherosclerosis, which, despite the systemic nature of major risk factors, occurs mainly at regions of arteries that experience disturbances in fluid flow. Read more »
Category: Endothelial and Smooth Muscle Tags:
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature
http://www.pnas.org –
Atherosclerotic lesion localization to regions of disturbed flow within certain arterial geometries, in humans and experimental animals, suggests an important role for local hemodynamic forces in atherogenesis. To explore how endothelial cells (EC) acquire functional/dysfunctional phenotypes in response to vascular region-specific flow patterns, we have used an in vitro dynamic flow system to accurately reproduce arterial shear stress waveforms on cultured human EC and have examined the effects on EC gene expression by using a high-throughput transcriptional profiling approach. Read more »
Year of publication:
2004
Journal name:
Proceedings of the National Academy of Sciences
Mechanisms of Mechanotransduction
http://www.sciencedirect.com –
The conversion of physical force into biochemical information is fundamental to development and physiology. It provides a simple means by which cells and organisms can ensure structural stability, as well as a way to regulate morphogenetic movements to generate precise three-dimensional structures. In the vascular system, pressure and shear stress from pumping blood influence the morphology and pathology of the heart and vasculature. Bone is shaped by forces from gravity and muscle contraction. Hearing and touch are based on neural responses to pressure. Read more »
Year of publication:
2006
Journal name:
Developmental Cell
Category: Cell Mechanotransduction Tags: