http://www.ncbi.nlm.nih.gov – Binding of platelets to fibrinogen via integrin alphaIIbbeta3 stimulates cytoskeletal reorganization and spreading. These responses depend on tyrosine phosphorylation of multiple proteins by Src family members and Syk. Among Src substrates in platelets is ADAP, an adapter with three potential binding partners, SLP-76, VASP and SKAP-HOM. During studies of platelet function under shear flow, we discovered that ADAP(-/-) mouse platelets, unlike ADAP(+/+) platelets, formed unstable rather than stable thrombi in response to carotid artery injury. Read more »