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NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction

http://www.sciencemag.org
Year of publication: 
2003
Journal name: 
Science
The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Read more »
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Created by shlee 2 years 21 weeks ago
Category: Cell Mechanotransduction   Tags:

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