Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k and protein synthesis.
http://www.ncbi.nlm.nih.gov –
The skeletal muscle is a tissue with adaptive properties which are essential to the survival of many species. When mechanically stimulated it is liable to undergo remodeling, namely, changes in its mass/volume resulting mainly from myofibrillar protein accumulation. The mTOR pathway (mammalian target of rapamycin) via its effector p70s6k (ribosomal protein kinase S6) has been reported to be of importance to the control of skeletal muscle mass, particularly under mechanical stimulation. Read more »
Category: Skeletal Muscle Cells Tags:
Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy.
http://www.ncbi.nlm.nih.gov –
Skeletal muscle is able not only to increase its mass as an adaptation to mechanical loading generated by and imposed upon muscle but also to regenerate after damage, via its intrinsic regulation of gene transcription. Both cellular processes, muscle regeneration and hypertrophy, are mediated by the activation, proliferation and differentiation of muscle satellite cells and appear to be modulated by the mitotic and myogenic activity of locally produced insulin-like growth factor 1 (IGF-1), which functions in an autocrine/paracrine mode. Read more »
Category: Skeletal Muscle Cells Tags:
Mechanical signal transduction in skeletal muscle growth and adaptation.
http://www.ncbi.nlm.nih.gov –
The adaptability of skeletal muscle to changes in the mechanical environment has been well characterized at the tissue and system levels, but the mechanisms through which mechanical signals are transduced to chemical signals that influence muscle growth and metabolism remain largely unidentified. However, several findings have suggested that mechanical signal transduction in muscle may occur through signaling pathways that are shared with insulin-like growth factor (IGF)-I. Read more »
Category: Skeletal Muscle Cells Tags:
Mechanotransduction in skeletal muscle
http://www.ncbi.nlm.nih.gov –
Mechanical signals are critical to the development and maintenance of skeletal muscle, but the
mechanisms that convert these shape changes to biochemical signals is not known. When a deformation is imposed on a muscle, changes in cellular and molecular conformations link the Read more »
Year of publication:
2008
Journal name:
Front Biosci
Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review
http://content.karger.com –
The abnormal physiology that manifests itself in healthy humans during their adaptation to the microgravity of space has all the features of accelerated aging. The mechano-skeletal and vestibulo-neuromuscular stimuli which are below threshold in space, result in an overall greater than 10-fold more rapid onset and time course of muscle and bone atrophy in space and the development of balance and coordination problems on return to Earth than occur with aging. Read more »
Year of publication:
2009
Journal name:
Gerontology