Tissue Mechanotransduction

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foreign language translation

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Mechanotransduction in development: a growing role for contractility

http://www.seas.upenn.edu
Year of publication: 
2009
Journal name: 
Nature
Mechanotransduction research has focused historically on how externally applied forces can affect cell signalling and function. A growing body of evidence suggests that contractile forces that are generated internally by the actomyosin cytoskeleton are also important in regulating cell behaviour, and suggest a broader role for mechanotransduction in biology. Although the molecular basis for these cellular forces in mechanotransduction is being pursued in cell culture, researchers are also beginning to appreciate their contribution Read more »
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Created by esoohoo 31 weeks 1 day ago
Category: Tissue Mechanotransduction   Tags:
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Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading

http://smartech.gatech.edu
Year of publication: 
2006
Journal name: 
Georgia Tech Theses and Dissertations
Disease and degeneration of articular cartilage and fibrocartilage tissues severely compromise the quality of life for millions of people. Although current surgical repair techniques can address symptoms in the short term, they do not adequately treat degenerative joint diseases such as osteoarthritis. Thus, novel tissue engineering strategies may be necessary to combat disease progression and repair or replace damaged tissue. Read more »
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Mechanotransduction in the Lung; Ventilation-induced lung injury and mechanotransduction: stretching it too far?

http://ajplung.physiology.org
Year of publication: 
2001
Journal name: 
The American Physiological Society
The Acute Respiratory Distress Syndrome Network clinical trial on ventilation of critically ill patients has drawn attention to the potential side effects of mechanical ventilation. Both clinical and basic research have demonstrated that injurious ventilation strategies can initiate or perpetuate local and systemic inflammatory responses. There are four principal mechanisms that can produce such a response. Read more »
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Mechanotransduction in Bone - role of the lacuno-canalicular network

http://www.fasebj.org
Year of publication: 
1999
Journal name: 
The FASEB Journal
The capacity of bone tissue to alter its mass and structure in response to mechanical demands has long been recognized but the cellular mechanisms involved remained poorly understood. Over the last several years significant progress has been made in this field, which we will try to summarize. These studies emphasize the role of osteocytes as the professional mechanosensory cells of bone, and the lacuno-canalicular porosity as the structure that mediates mechanosensing. Read more »
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Created by rose_leu 31 weeks 2 days ago – Made popular 31 weeks 1 day ago
Category: Tissue Mechanotransduction   Tags:
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Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

http://www.pnas.org
Year of publication: 
2009
Journal name: 
PNAS
Physical forces generated by cells drive morphologic changes during development and can feedback to regulate cellular phenotypes. Because these phenomena typically occur within a 3-dimensional (3D) matrix in vivo, we used microelectromechanical systems (MEMS) technology to generate arrays of microtissues consisting of cells encapsulated within 3D micropatterned matrices. Microcantilevers were used to simultaneously constrain the remodeling of a collagen gel and to report forces generated during this process. By concurrently measuring forces and observing matrix remodeling Read more »
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Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage

http://www.sciencedirect.com
Year of publication: 
2010
Journal name: 
Osteoarthritis and Cartilage
Summary Objective Osteoarthritis is a disease process of cellular degradation of articular cartilage caused by mechanical loads and inflammatory cytokines. We studied the cellular response in native cartilage subjected to a mechanical load administered simultaneously with an inflammatory cytokine interleukin-1 (IL-1), hypothesizing that the combination of load and cytokine would result in accelerated extracellular matrix (ECM) degradation. Methods Read more »
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Created by sgirn 31 weeks 2 days ago – Made popular 31 weeks 2 days ago
Category: Tissue Mechanotransduction   Tags:
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Regenerative Medicine Special Feature: Enabling tools for engineering collagenous tissues...

http://www.ncbi.nlm.nih.gov
Year of publication: 
2009
Journal name: 
PubMed
Many investigators have engineered diverse connective tissues having good mechanical properties, yet few tools enable a global understanding of the associated formation of collagen fibers, the primary determinant of connective tissue stiffness. Toward this end, we developed a biomechanical model for collagenous tissues grown on polymer scaffolds that accounts for the kinetics of polymer degradation as well as the synthesis and degradation of multiple families of collagen fibers in response to cyclic strains imparted in a bioreactor. Read more »
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Created by albertpeng 31 weeks 2 days ago – Made popular 31 weeks 2 days ago
Category: Tissue Mechanotransduction   Tags:
2

The Finite Element Method: a Tool to Study Orthodontic Tooth Movement

http://jdr.sagepub.com
Year of publication: 
2005
Journal name: 
Journal of Dental Research
Orthodontic tooth movement is achieved by (re)modeling processes of the alveolar bone, which are triggered by changes in the stress/strain distribution in the periodontium. In the past, the finite element (FE) method has been used to describe the stressed situation within the periodontal ligament (PDL) and surrounding alveolar bone. The present study sought to determine the impact of the modeling process on the outcome from FE analyses and to relate these findings to the current theories on orthodontic tooth movement. Read more »
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Created by Amir Mehdizadeh 31 weeks 2 days ago – Made popular 31 weeks 2 days ago
Category: Tissue Mechanotransduction   Tags:

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