Year of publication:
2005
Journal name:
JOURNAL OF BIOMECHANICAL ENGINEERING
Finite-Element Analysis of the Adhesion-Cytoskeleton-Nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model
http://www.seas.upenn.edu –
Endothelial cells possess a mechanical network connecting adhesions on the basal surface,
the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway
can deform the nucleus, ultimately resulting in an alteration of gene expression and
other cellular changes (mechanotransduction). Previously, we measured cell adhesion
area and apparent nuclear stretch during endothelial cell rounding. Here, we reconstruct
the stress map of the nucleus from the observed strains using finite-element modeling. To Read more »
Category: Adherens Junctions Tags:
Nitric oxide and cyclic nucleotides: Their roles in junction dynamics and spermatogenesis
http://www.ncbi.nlm.nih.gov –
Spermatogenesis is a highly complicated process in which functional spermatozoa (haploid, 1n) are generated from primitive mitotic spermatogonia (diploid, 2n). This process involves the differentiation and transformation of several types of germ cells as spermatocytes and spermatids undergo meiosis and differentiation. Due to its sophistication and complexity, testis possesses intrinsic mechanisms to modulate and regulate different stages of germ cell development under the intimate and indirect cooperation with Sertoli and Leydig cells, respectively. Read more »
Year of publication:
2008
Journal name:
Landes Bioscience