http://www.fasebj.org –
Growing stem cells are subjected to mechanical
forces, which may initiate differentiation programs.
Mechanical strain stimulated cardiovascular differentiation
of mouse embryonic stem (ES) cells as
evaluated by quantification of contracting cardiac foci
and capillary areas, respectively. Mechanical strain rapidly
elevated intracellular reactive oxygen species
(ROS). After 24 h up-regulation of NADPH oxidase
subunits p22-phox, p47-phox, p67-phox, and Nox-4 as
well as Nox-1 and Nox-4 mRNA was observed. In parallel,
mechanical strain increased hypoxia-inducible factor-
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Created by johnny5550822
31 weeks 3 days ago
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