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Mens North confront Windstopper is chic, but in add-on waterproof, breathable and consists of a thermal Heat seeker Eco insulation to retain you cozy all day time long. The adjustable waist will permit you to definitely possess a flattering suit as well as the 4-button the front provides this glimpse an experienced feel. Read more »
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Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
http://www.sciencemag.org –
The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN inhibited cell migration, whereas antisense PTEN enhanced migration. Integrin-mediated cell spreading and the formation of focal adhesions were down-regulated by wild-type PTEN but not by PTEN with an inactive phosphatase domain. PTEN interacted with the focal adhesion kinase FAK and reduced its tyrosine phosphorylation. Overexpression of FAK partially antagonized the effects of PTEN. Read more »
Year of publication:
1998
Journal name:
Science
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
http://cancerres.aacrjournals.org –
Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system associated with a median survival time of 15 months, even with aggressive therapy. This rapid progression is due in part to diffuse infiltration of single tumor cells into the brain parenchyma, which is thought to involve aberrant interactions between tumor cells and the extracellular matrix (ECM). Here, we test the hypothesis that mechanical cues from the ECM contribute to key tumor cell properties relevant to invasion. Read more »
Year of publication:
2009
Journal name:
Cancer Research 69
Focal adhesion kinase-dependent regulation of adhesive force involves vinculin recruitment to focal adhesions.
http://www.biolcell.org –
Background information. Focal adhesion kinase (FAK), an essential non-receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signaling, and mechanotransduction. FAK-dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion. Whereas roles for FAK in migratory and mechanosensing responses have been established, the contributions of FAK to the generation of adhesive forces are not well understood. Results. Read more »
Year of publication:
2009
Journal name:
Biology of the Cell