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http://mechanotransduction.org –
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
http://www.sciencemag.org –
Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin. The behavior of some cells on soft materials is characteristic of important phenotypes; for example, cell growth on soft agar gels is used to identify cancer cells. Read more »
Year of publication:
2005
Journal name:
Science
Genes, forces, and forms: Mechanical aspects of prenatal craniofacial development
http://www3.interscience.wiley.com –
Current knowledge of molecular signaling during craniofacial development is advancing rapidly. We know that cells can respond to mechanical stimuli by biochemical signaling. Thus, the link between mechanical stimuli and gene expression has become a new and important area of the morphological sciences. This field of research seems to be a revival of the old approach of developmental mechanics, which goes back to the embryologists His ([1874]), Carey ([1920]), and Blechschmidt ([1948]). These researchers argued that forces play a fundamental role in tissue differentiation and morphogenesis. Read more »
Year of publication:
2006
Journal name:
Developmental Dynamics
TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION
http://arjournals.annualreviews.org –
Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g. stretch-sensitive ion channels, signaling mollecules, cytoskeleton, integrins) within the context of the structural complexity of living cells. The model presented relies on recent experimental findings, which suggests that cells use tensegrity architecture for their organization. Read more »
Year of publication:
1997
Journal name:
Annual Review of Physiology
The Role of the Calmodulin-Dependent Pathway in Static Magnetic Field-Induced Mechanotransduction
http://www3.interscience.wiley.com –
Abstract Read more »
Year of publication:
2009
Journal name:
Bioelectromagnetics