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indirmeden film izle, bedava film izle, online film ve video izleme sitesi sizler için tasarlandı ve sizler için hergün güncellenmete Read more »
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Stem cell fate dictated solely by altered nanotube dimension
http://www.ncbi.nlm.nih.gov –
Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, we demonstrate such paths by controlling only the nanotopography of culture substrates. Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media. Read more »
Year of publication:
2008
Journal name:
The National Academy of Sciences of the USA
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A prediction of cell differentiation and proliferation within a CG scaffold subjected to mechanical strain and perfusive fluid flow
http://www.sciencedirect.com –
Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell responses are thus far underdeveloped. This investigation attempted to simulate cell responses in a collagen–glycosaminoglycan (CG) scaffold within a bioreactor. CG scaffold deformation was simulated using μ-computed tomography (CT) and an in-house finite element solver (FEEBE/linear). Read more »
Year of publication:
2009
Journal name:
Journal of Biomechanics
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Matrix Elasticity Directs Stem Cell Lineage Specification
http://www.cell.com –
Microenvironments appear important in stem cell lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive mesenchymal stem cells (MSCs) are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity. Soft matrices that mimic brain are neurogenic, stiffer matrices that mimic muscle are myogenic, and comparatively rigid matrices that mimic collagenous bone prove osteogenic. Read more »
Year of publication:
2006
Journal name:
Cell
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Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation
http://www.fasebj.org –
Growing stem cells are subjected to mechanical
forces, which may initiate differentiation programs.
Mechanical strain stimulated cardiovascular differentiation
of mouse embryonic stem (ES) cells as
evaluated by quantification of contracting cardiac foci
and capillary areas, respectively. Mechanical strain rapidly
elevated intracellular reactive oxygen species
(ROS). After 24 h up-regulation of NADPH oxidase
subunits p22-phox, p47-phox, p67-phox, and Nox-4 as
well as Nox-1 and Nox-4 mRNA was observed. In parallel,
mechanical strain increased hypoxia-inducible factor- Read more »
Year of publication:
2006
Journal name:
The FASEB Journal
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MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation
http://ajpcell.physiology.org –
Mechanical signals are important regulators of skeletal homeostasis, and strain-induced oscillatory fluid flow is a potent mechanical stimulus. Although the mechanisms by which osteoblasts and osteocytes respond to fluid flow are being elucidated, little is known about the mechanisms by which bone marrow-derived mesenchymal stem cells respond to such stimuli. Here we show that the intracellular signaling cascades activated in human mesenchymal stem cells by fluid flow are similar to those activated in osteoblastic cells. Read more »
Year of publication:
2005
Journal name:
Am J Physiol Cell Physiol 290


