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Mechanotransduction and strain amplification in osteocyte cell processes
http://www.pnas.org –
A paradox in bone tissue is that tissue-level strains due to animal and human locomotion are too small to initiate intracellular chemical responses directly. A model recently was proposed to resolve this paradox, which predicts that the fluid flow through the pericellular matrix in the lacunar-canalicular porosity due to mechanical loading can induce strains in the actin filament bundles of the cytoskeleton that are more than an order of magnitude larger than tissue level strains. Read more »
Year of publication:
2004
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PNAS
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http://jcs.biologists.org –
Water is the dominant ingredient of cells and its dynamics are crucial to life. We and others have suggested a physical picture of the cell as a soft, fluid-infiltrated sponge, surrounded by a water-permeable barrier. To understand water movements in an animal cell, we imposed an external, inhomogeneous osmotic stress on cultured cancer cells. This forced water through the membrane on one side, and out on the other. Inside the cell, it created a gradient in hydration, that we visualized by tracking cellular responses using natural organelles and artificially introduced quantum dots. Read more »
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2009
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Journal of Cell Science.
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Cardiac mechanotransduction: from sensing to disease and treatment
http://www.sciencedirect.com –
In heart muscle a mechanical stimulus is sensed and transformed into adaptive changes in cardiac function by a process called mechanotransduction. Adaptation of heart muscle to mechanical load consists of neurohumoral activation and growth, both of which decrease the initial load. Under prolonged overload this process becomes maladaptive, leading to the development of left ventricular hypertrophy and ultimately to heart failure. Read more »
Year of publication:
2001
Journal name:
Trends in Pharmacological Sciences
Mechanotransduction in Response to Shear Stress: Roles of Receptor Tyrosine Kinases, Integrins, and Shc
http://www.jbc.org –
Shear stress, the tangential component of hemodynamic forces, activates many signal transduction pathways in vascular endothelial cells. The conversion of mechanical stimulation into chemical signals is still unclear. We report here that shear stress (12 dynes/cm2) induced a rapid and transient tyrosine phosphorylation of Flk-1 and its concomitant association with the adaptor protein Shc; these are accompanied by a concurrent clustering of Flk-1, as demonstrated by confocal microscopy. Read more »
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1999
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