Archived articles - Developmental Cells

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Tissue Cells Feel and Respond to the Stiffness of Their Substrate

http://www.sciencemag.org
Year of publication: 
2005
Journal name: 
Science
Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby's skin. The behavior of some cells on soft materials is characteristic of important phenotypes; for example, cell growth on soft agar gels is used to identify cancer cells. Read more »
wanderlust's picture
Created by wanderlust 2 years 20 weeks ago
Category: Developmental Cells   Tags:
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dadanramadhan's picture
Created by dadanramadhan 17 weeks 5 days ago
Category: Developmental Cells   Tags:
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Genes, forces, and forms: Mechanical aspects of prenatal craniofacial development

http://www3.interscience.wiley.com
Year of publication: 
2006
Journal name: 
Developmental Dynamics
Current knowledge of molecular signaling during craniofacial development is advancing rapidly. We know that cells can respond to mechanical stimuli by biochemical signaling. Thus, the link between mechanical stimuli and gene expression has become a new and important area of the morphological sciences. This field of research seems to be a revival of the old approach of developmental mechanics, which goes back to the embryologists His ([1874]), Carey ([1920]), and Blechschmidt ([1948]). These researchers argued that forces play a fundamental role in tissue differentiation and morphogenesis. Read more »
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