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the God of fire of later generations. Mammals in her house is not going to, so the thing on the island, I do not know. But now I'm a King Ant Commander all the ants. Ant soldiers have been trained throughout the forest, will be my command, very powerful lineup. Black stone of the witch wanted to win twice and I was beat back by me. But this time, we do not need to protect it, because the Queen once told me that if you get that means you can defeat the witch, forever free from the curse of the suffering. Read more »
loloaa's picture
Created by loloaa 19 weeks 1 day ago
Category: Cancer Cells   Tags:
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Cell tension, matrix mechanics, and cancer development

http://www.sciencedirect.com
Year of publication: 
2005
Journal name: 
Cancer Cell
Oncologists often diagnose cancer based on a change of tissue stiffness sensed by palpation, yet cancer researchers generally focus on biochemical signaling mechanisms. Tumors are more rigid because they have a stiffer extracellular matrix. A new study shows that this alteration of matrix mechanics activates integrins, which not only promotes mitogenic signaling through Erk but also cell contractility through Rho, which can further increase matrix stiffness. This establishes a positive feedback loop that switches on the malignant phenotype in mammary epithelial cells. Read more »
msylvia_bioe102's picture
Created by msylvia_bioe102 2 years 21 weeks ago
Category: Cancer Cells   Tags:
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Animal cell hydraulics

http://jcs.biologists.org
Year of publication: 
2009
Journal name: 
Journal of Cell Science.
Water is the dominant ingredient of cells and its dynamics are crucial to life. We and others have suggested a physical picture of the cell as a soft, fluid-infiltrated sponge, surrounded by a water-permeable barrier. To understand water movements in an animal cell, we imposed an external, inhomogeneous osmotic stress on cultured cancer cells. This forced water through the membrane on one side, and out on the other. Inside the cell, it created a gradient in hydration, that we visualized by tracking cellular responses using natural organelles and artificially introduced quantum dots. Read more »
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Created by dorothy_tulanont 2 years 21 weeks ago
Category: Cancer Cells   Tags:
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fashiang's picture
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Category: Cancer Cells   Tags:
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A tense situation: forcing tumour progression

http://www.ncbi.nlm.nih.gov
Year of publication: 
2009
Journal name: 
Nature Reviews Cancer
Cells within tissues are continuously exposed to physical forces including hydrostatic pressure, shear stress, and compression and tension forces. Cells dynamically adapt to force by modifying their behaviour and remodelling their microenvironment. They also sense these forces through mechanoreceptors and respond by exerting reciprocal actomyosin- and cytoskeletal-dependent cell-generated force by a process termed 'mechanoreciprocity'. Loss of mechanoreciprocity has been shown to promote the progression of disease, including cancer. Read more »
rscummings's picture
Created by rscummings 2 years 21 weeks ago
Category: Cancer Cells   Tags:
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Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria

http://www.sciencedirect.com
Year of publication: 
2005
Journal name: 
Journal of Molecular Biology
Bacteria can sense their environment, distinguish between cell types, and deliver proteins to eukaryotic cells. Here, we engineer the interaction between bacteria and cancer cells to depend on heterologous environmental signals. We have characterized invasin from Yersinia pseudotuburculosis as an output module that enables Escherichia coli to invade cancer-derived cells, including HeLa, HepG2, and U2OS lines. To environmentally restrict invasion, we placed this module under the control of heterologous sensors. Read more »
manutej's picture
Created by manutej 2 years 21 weeks ago
Category: Cancer Cells   Tags:
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