Published articles - Endothelial and Smooth Muscle

14

Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype.

http://www.ncbi.nlm.nih.gov
Year of publication: 
2005
Journal name: 
Journal of Applied Physiology
The vascular smooth muscle cell (VSMC) is surrounded by a complex extracellular matrix that provides and modulates a variety of biochemical and mechanical cues that guide cell function. Conventional two-dimensional monolayer culture systems recreate only a portion of the cellular environment, and therefore there is increasing interest in developing more physiologically relevant three-dimensional culture systems. Read more »
11

Endothelial mechanotransduction, nitric oxide and vascular inflammation.

http://www.ncbi.nlm.nih.gov Numerous aspects of vascular homeostasis are modulated by nitric oxide and reactive oxygen species (ROS). The production of these is dramatically influenced by mechanical forces imposed on the endothelium and vascular smooth muscle. In this review, we will discuss the effects of mechanical forces on the expression of the endothelial cell nitric oxide synthase, production of ROS and modulation of endothelial cell glutathione. Read more »
12

Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with.

http://www.ncbi.nlm.nih.gov The vascular endothelium is a dynamic cellular interface between the vessel wall and the bloodstream, where it regulates the physiological effects of humoral and biomechanical stimuli on vessel tone and remodeling. With respect to the latter hemodynamic stimulus, the endothelium is chronically exposed to mechanical forces in the form of cyclic circumferential strain, resulting from the pulsatile nature of blood flow, and shear stress. Read more »
13

Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts.

http://www.ncbi.nlm.nih.gov Understanding how vascular wall endothelial cells (ECs), smooth muscle cells (SMCs), and fibroblasts (FBs) sense and transduce the stimuli of hemodynamic forces (shear stress, cyclic strain, and hydrostatic pressure) into intracellular biochemical signals is critical to prevent vascular disease development and progression. ECs lining the vessel lumen directly sense alterations in blood flow shear stress and then communicate with medial SMCs and adventitial FBs to regulate vessel function and disease. Shear stress mechanotransduction in ECs has been extensively studied and reviewed. Read more »
15

Mechanotransduction in vascular physiology and atherogenesis.

http://www.ncbi.nlm.nih.gov Forces that are associated with blood flow are major determinants of vascular morphogenesis and physiology. Blood flow is crucial for blood vessel development during embryogenesis and for regulation of vessel diameter in adult life. It is also a key factor in atherosclerosis, which, despite the systemic nature of major risk factors, occurs mainly in regions of arteries that experience disturbances in fluid flow. Read more »
5

Mechanotransduction in vascular physiology and atherogenesis

http://www.ncbi.nlm.nih.gov:80
Year of publication: 
2009
Journal name: 
Nat Rev Mol Cell Bio
Forces associated with blood flow are major determinants of vascular morphogenesis and physiology. Blood flow is crucial for blood vessel development during embryogenesis and for regulation of vessel diameter in adult life. It is also a key factor in atherosclerosis, which, despite the systemic nature of major risk factors, occurs mainly at regions of arteries that experience disturbances in fluid flow. Read more »
creber's picture
Created by creber 3 years 21 weeks ago – Made popular 3 years 21 weeks ago
Category: Endothelial and Smooth Muscle   Tags:
5

Mechnotransduction and Endothelial Cell Homeostasis: the Wisdom of the Cell

http://ajpheart.physiology.org
Year of publication: 
2006
Journal name: 
AJP - Heart and Circulatory Physiology
Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions. Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure and flow, modulate EC functions by activating mechanosensors, signaling pathways, and gene and protein expressions. Read more »
rose_leu's picture
Created by rose_leu 3 years 21 weeks ago – Made popular 3 years 21 weeks ago
Category: Endothelial and Smooth Muscle   Tags:
2

Endostatin Induces Endothelial Cell Apoptosis

http://www.jbc.org
Year of publication: 
1999
Journal name: 
The Journal of Biological Chemistry
Endostatin, a carboxyl-terminal fragment of collagen XVIII, has been shown to regress tumors in mice. In this study, we have analyzed the mechanism of endostatin action on endothelial cells and nonendothelial cells. Endostatin treatment of cow pulmonary artery endothelial cells caused apoptosis, as demonstrated by three methods, annexin V-fluorescein isothiocyanate staining, caspase 3, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling assay. Read more »
lloydjlee's picture
Created by lloydjlee 3 years 21 weeks ago – Made popular 3 years 21 weeks ago
Category: Endothelial and Smooth Muscle   Tags:
2

Upstream mechanotaxis behavior of endothelial cells

http://www.ncbi.nlm.nih.gov
Year of publication: 
2009
Journal name: 
PubMed
Vascular endothelial cell migration, which plays an important role in vascular remodeling, is known to be regulated by hemodynamic forces in the blood vessels. When shear stress is applied on mouse microvessel endothelial cells (bEnd.3) in vitro, cells exhibit upstream migration behavior with respect to the direction of the flow. To determine how shear stress magnitude influences mechanotaxis of the cells, endothelial cells were exposed to different magnitudes of unidirectional shear stress. Read more »
5

Effects of cyclic stretch on proliferation of mesenchymal stem cells and their differentiation to smooth muscle cells

http://www.sciencedirect.com
Year of publication: 
2009
Journal name: 
Biochemical and Biophysical Research Communications
Bone marrow mesenchymal stem cells (MSCs) are capable of differentiating into a variety of cell types such as vascular smooth muscle cells (SMCs). In this study, we investigated influence of cyclic stretch on proliferation of hMSCs for different loading conditions, alignment of actin filaments, and consequent differentiation to SMCs. Isolated cells from bone marrow were exposed to cyclic stretch utilizing a customized device. Cell proliferation was examined by MTT assay, alignment of actin fibers by a designed image processing code, and cell differentiation by fluorescence staining. Read more »
yuanfangfu8910's picture
Created by yuanfangfu8910 3 years 23 weeks ago – Made popular 3 years 23 weeks ago
Category: Endothelial and Smooth Muscle   Tags:

Search

User login